منابع مشابه
Corticotropins (acth)
Purified alpha-corticotropin has been reported to exercise the following biological effects: (a) stimulation of the adrenal glands in normal and hypophysectomized rats, (b) production of blood eosinopenia in hypophysectomized rats, (c) maintenance of muscle glycogen in hypophysectomized rats, (d) inhibition of growth-promoting activity of somatotropin, (e) stimulation of melanocytes in the skin...
متن کاملAcquired resistance to corticotropins.
Corticotropin, which may be defined as a pituitary extract that will directly stimulate the adrenal cortex to secrete its predominantly "glucocorticoid" hormones, has been in general use for about 5 years. In spite of this, its use as a therapeutic agent has not been defined. There are two reasons for this state of affairs. The first is that most physicians have assumed that the administration ...
متن کاملACTH Antagonists
Adrenocorticotropin (ACTH) acts via a highly selective receptor that is a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors. The ACTH receptor, also known as the melanocortin 2 receptor (MC2R), is unusual in that it is absolutely dependent on a small accessory protein, melanocortin receptor accessory protein (MRAP) for cell surface expression and function. ACTH...
متن کاملHuman corticotropin (ACTH) radioimmunoassay with synthetic 1--24 ACTH.
A corticotropin antiserum was obtained from rabbits immunized with synthetic 1--24 corticotropin conjugated with bovine serum albumin. The antiserum did not cross react with synthetic alpha-melanotropin or with synthetic beta-endorphin and had a cross reactivity of 0.23% with human beta-lipotropin. We developed a radioimmunoassay with the antiserum obtained, in which we used polyethylene glycol...
متن کاملCross - Reactivity of Antiserum to ACTH With ACTH
Adrenocorticotropin (ACTH) and/3-1ipotropin (/3-LPH) have been localized by immunoperoxidase methods in nerve cells and fibers of the hypothalamus and brain stem of the ewe. 6-~m sections were immunostained first for either ACTH or/3-LPH. The reaction products and the antibody complexes were then eluted completely from the tissue, and the same section was immunostained for the second peptide. A...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1955
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)98182-2